Preparación de productos con propóleos para el tratamiento de candidiasis vaginal

lunes 28 de enero de 2013
http://onlinelibrary.wiley.com/doi/10.1002/jps.23451/abstract

Se evaluó la preparación de productos con propóleos para el tratamiento de candidiasis vaginal

Conclusiones
La actividad antimicrobiana in vitro de los preparados se evaluó frente a microorganismos de importancia vaginal (Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, y Saccharomyces cerevisiae), que muestran actividad contra todas las levaduras probadas. Los datos obtenidos para estos sistemas indicar un papel potencialmente útiles en el tratamiento de VVC y sugieren que son dignos de evaluación clínica. © 2013 Wiley Periodicals, Inc. y la Asociación Americana de Farmacéuticos J Pharm Sci

Preparation and characterization of mucoadhesive thermoresponsive systems containing propolis for the treatment of vulvovaginal candidiasis

1. Raphaela Regina de Araújo Pereira¹,
2. Janine Silva Ribeiro Godoy², 
3. Terezinha Inez Stivalet Svidzinski², 
4. Marcos Luciano Bruschi^1,*

Article first published online: 18 JAN 2013

DOI: 10.1002/jps.23451

Copyright © 2013 Wiley Periodicals, Inc.

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Journal of Pharmaceutical Sciences

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Keywords:

• biodegradable polymers;
• natural products;
• mechanical properties;
• hydrogels;
• mucosal drug delivery;
• rheology

Abstract

This work describes the preparation and characterization of mucoadhesive thermoresponsive systems consisted of poloxamer 407 (P407), Carbopol® 934P (C934P), and propolis to treat vulvovaginal candidiasis (VVC). Systems were obtained with different percentages of P407 and C934P to deliver propolis, a potent drug against VVC. Temperature of gelation, hardness, compressibility, adhesiveness, elasticity, cohesiveness, mucoadhesion, rheology (continuous flow and oscillatory), in vitro drug release, and antimicrobial activity were evaluated. Increasing the polymer content or temperature and the drug presence significantly increased mechanical properties of formulations. These exhibited pseudoplastic flow and low degrees of thixotropy. In most samples, increasing the C934P content significantly changed the oscillatory rheological properties. Formulations showed thermoresponsive behavior, existing as a liquid at room temperature and gel at 34°C–37°C. Propolis release from formulations was controlled by phenomenon of relaxation of polymer chains or displayed anomalous behavior, dependent of concentration of each polymer. The in vitro antimicrobial activity of preparations was evaluated against microorganisms of vaginal importance (Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Saccharomyces cerevisiae), displaying activity against all yeast tested. The data obtained for these systems indicate a potentially useful role in the treatment of VVC and suggest they are worthy of clinical evaluation. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci

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